1. Nakashima et al. (12) report that The inhibition of PLA2 activity by
2. quinacrine effectively supresses the paf- quinacrine could possibly lead to a dimin
3. induced liberation of [3H]-AA from phos- ished Ca 2+ availability and not to a direct
4. pholipids in human polymorphonuclear inhibition of the enzyme itself.
5. neutrophils. In this case extracellular Ca 2+ Once activated PLA2 can mediate a