A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.

Author:

Clewell Harvey J1,Andersen Melvin E1,Barton Hugh A1

Affiliation:

1. Environ International Corp., Ruston, Louisiana 71270, USA. hclewell@environcorp.com

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference55 articles.

1. Risk Assessment Extrapolations and Physiological Modeling

2. Biologically Motivated Models for Chemical Risk Assessment

3. Tissue Dosimetry, Pharmacokinetic Modeling, and Interspecies Scaling Factors

4. Oberdorster G. Deposition and retention modeling of inhaled cadmium in rat and human Iung: an example for extrapolation of effects and risk estimation. In: Extrapolation of Dosimetric Relationships for Inhaled Particles and Gases (Crapo JD Smolko ED Miller FJ Graham JA Hayes AW eds). San Diego CA:Academic Press 1989;345-370.

5. Oberdorster G. Equivalent oral and inhalation exposure to cadmium compounds: risk estimation based on routeto-route extrapolation. In: Principles of Route-to-Route Extrapolation for Risk Assessment (Gerrity TR Henry CJ eds). New York:Elsevier 1990;217-235.

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