Deviation from additivity in mixture toxicity: relevance of nonlinear dose-response relationships and cell line differences in genotoxicity assays with combinations of chemical mutagens and gamma-radiation.

Author:

Lutz Werner K1,Vamvakas Spyros1,Kopp-Schneider Annette1,Schlatter Josef1,Stopper Helga1

Affiliation:

1. Department of Toxicology, University of Würzburg, Würzburg, Germany. lutz@toxi.uni-wuerzburg.de

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference27 articles.

1. THE TOXICITY OF POISONS APPLIED JOINTLY1

2. ICRU Report. Quantitative Concepts and Dosimetry in Radiobiology Vol 30. Ashford England:Nuclear Technology Publishing 1979.

3. assessments of synergism];Lystsov VN;Radiobiologiia,1985

4. Health risks from combined exposures: mechanistic considerations on deviations from additivity

5. UNSCEAR Report. Sources and Effects of Ionizing Radiation. Vol 2: Effects. New York:United Nations Sales Publications 2000.

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