Nanosize Titanium Dioxide Stimulates Reactive Oxygen Species in Brain Microglia and Damages Neurons in Vitro

Author:

Long Thomas C.1,Tajuba Julianne1,Sama Preethi1,Saleh Navid2,Swartz Carol1,Parker Joel3,Hester Susan4,Lowry Gregory V.2,Veronesi Bellina4

Affiliation:

1. Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA

2. Department of Civil and Environmental Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

3. Constella Inc., Research Triangle Park, North Carolina, USA

4. National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference46 articles.

1. Comparative toxicity of nano-scale TiO2, SiO2 and ZnO water suspensions

2. Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide

3. Affymetrix Inc. 2004. Affymetrix Technical Manual Available: www.expressionanalysis.comm [accessed 2 October 2007].

4. Ubiquinone: metabolism and functions. Ubiquinone deficiency and its implication in mitochondrial encephalopathies. Treatment with ubiquinone;Artuch R;Rev Neurol,1999

5. Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages.

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