Investigating the volume of hippocampus and corpus callosum in Iranian multiple sclerosis patients using magnetic resonance imaging: a retrospective study

Abstract

Multiple Sclerosis (MS) is one of the most common forms of the acquired autoimmune demyelinating disorder affecting the brain. The neurological symptoms of MS are often presented in a relapsing-remitting manner. This study aims to investigate volume changes in the hippocampus and Corpus Callosum (CC). A cross-sectional study was conducted on 200 MS patients, 100 males and 100 females, aged 20-56 years. According to McDonald’s 2017 criteria,100 patients were in the MS group, and 100 were in the control group. This study assessed volume changes in the hippocampus and CC with ITK-SNAP 4.0 software. Our study revealed that the volumes of the right Hippocampus (P<0.0001), left Hippocampus (P<0.05), and corpus callosum (P<0.001), were significantly decreased in MS group compared to control group, regardless of the sex of the patients. Additionally, our results showed that the volume of these three areas has no significant difference with the age of MS patients. This research shows that some brain regions, including the hippocampus and corpus callosum, can be essential landmarks in determining MS disease.