Fecal microbiota and Clostridium transplantation: Strategies for intestinal balance

Abstract

Introduction: fecal Matter Transplantation is a method based on the administration of a processed and prepared fecal suspension from a healthy individual to another patient with the aim of restoring intestinal microbiota balance by manipulating the microbiota to the carrier of the specific disease with the goal of achieving its resolution. Objectives: to describe the scientific evidence on fecal microbiota transplantation strategies to restore intestinal balance and reduce Clostridium difficile infections. Material and methods: a Systematic Review of the literature was carried out, which will be governed according to PRISMA guidelines. The units of analysis will be abstracts and full text of articles with randomized clinical trial design or prospective or retrospective cohort, published in Scopus, Web of Science and Pubmed, without temporal restriction. Results: the results of this review support the efficacy of FMT in the treatment of CRID and provide valuable information on the restoration of intestinal balance. However, further research and rigorous clinical trials are required to fully understand the mechanisms underlying these effects and to optimize treatment protocols. FMT has the potential to be a valuable tool in clinical practice and in the fight against recurrent intestinal infections, as well as in reducing antibiotic resistance.