Literature review interpretation of novel bacteriophage treatments for skin diseases

Abstract

The justification for researching novel treatments with bacteriophages for skin diseases lies in the urgent need to overcome the challenges posed by antibiotic resistance. The aim of this study was to interpret, through bibliographic review, novel treatments with bacteriophages in skin diseases. A comprehensive search strategy was developed in highly recognized academic and scientific databases, including PUBMED, MEDLINE, Scopus, Clinical Key, and Web of Science. The selection of key terms was based on an iterative process that included "bacteriophages", "phages", "treatment", "phage therapy", "skin diseases", "dermatology", and "clinical applications". This strategy was complemented by the application of filters to restrict the results to publications between the years 2019 and 2023. The results of the reviewed studies suggested clinical resolution in approximately half of the cases treated with phage therapy, highlighting its effectiveness against resistant bacterial infections. However, it was noted that more rigorous clinical trials were required to establish its long-term efficacy and safety. The emerging bacteriophage therapy industry showed a diversity of companies and strategies, promoting its growth in the medical community. It was concluded that bacteriophages represent a promising addition to the medical arsenal and a hopeful response to antimicrobial resistance. The review reflected how science and medicine collaborated to address a crucial global challenge, offering innovative solutions in the treatment of bacterial infections