Olfactory Bulb Lesion Induced Pineal Gland Calcification: a First Experimental Study

Abstract

Objectives: There is no enough stereological study that seriously mentions maternal olfactory disorders among the causes of pineal gland insults. This study sought to examine the connection between lesions caused by olfactory bulbectomy and changes in the pineal gland in rats Methods: A total of 24 male rats were used in the experiment, 5 control, 6 SHAM and 13 study. After a 1 mm burrhole was opened in the midfrontal-interpupillary line for the subjects in the SHAM and study groups, only the olfactory dura was opened in the SHAM group, while the olfactory bulbs were crushed in study group. They were sacrificed after a two-month follow-up. The number of calcified pineal cells (n/mm3) determined. Results analyzed with the Mann-Witney U test. Results: The mean calcified pineal cells numbers (n/mm3) were measured as per cubic milimeters as: (7±2) x103/mm3) in control (Group I); (15±3) x103 in SHAM (Group II); (34±9) x103 in study group (Group III). P