Author:
He Qian-Jun,Li Yi-Fei,Zhao Ling-Tong,Lin Chun-Tong,Yu Chun-Yan,Wang Dan
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause of chronic liver disease. In recent years, an increasing amount of data suggests that MASLD is associated with aging. As the population ages, age-related MASLD will become a major global health problem. Targeting an aging will become a new approach to the treatment of MASLD. This paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD, including: Oxidative stress, autophagy, mitochondrial homeostasis, bile acid metabolism homeostasis, and dysbiosis. The aim is to identify effective therapeutic targets for age-related MASLD and its progression.
Publisher
Baishideng Publishing Group Inc.
Reference71 articles.
1. Hallmarks of aging: An expanding universe
2. National Institutes of Health. National Institute on Aging, Global Health & Aging 2011. Available from: https://www.nia.nih.gov/research/publication/global-health-and-aging/health-and-work
3. Cellular Senescence in Cancer and Aging
4. Cellular senescence: the good, the bad and the unknown
5. Mechanisms of NAFLD development and therapeutic strategies
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献