Author:
Choi Yoon Jin,Kim Tae Jun,Bang Chang Seok,Lee Yong Kang,Lee Moon Won,Nam Su Youn,Shin Woon Geon,Seo Seung In
Abstract
BACKGROUND
The clinical trend and characteristics of peptic ulcer disease (PUD) have not fully been investigated in the past decade.
AIM
To evaluate the changing trends and characteristics of PUD according to age and etiology.
METHODS
We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and 2019. We classified patients with PUD who underwent rapid urease tests or Helicobacter pylori (H. pylori ) serology into three groups: H. pylori -related, drug [nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin]-related, and idiopathic (H. pylori /NSAID/aspirin-negative) PUD and compared the yearly trends and characteristics among the three groups.
RESULTS
We included 26785 patients in 7 databases, and the proportion of old age (≥ 65 years) was 38.8%. The overall number of PUD exhibited no decrease, whereas PUD in old age revealed an increasing trend (P = 0.01 for trend). Of the 19601 patients, 41.8% had H. pylori -related, 36.1% had drug-related, and 22.1% had idiopathic PUD. H. pylori -related PUD exhibited a decreasing trend after 2014 (P = 0.01), drug-related PUD demonstrated an increasing trend (P = 0.04), and idiopathic PUD showed an increasing trend in the old-age group (P = 0.01) during 10 years. Patients with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic drugs. The idiopathic PUD group had a significantly higher number of patients with chronic liver disease.
CONCLUSION
With the aging population increase, the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced PUD. Further studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.
Publisher
Baishideng Publishing Group Inc.
Subject
Gastroenterology,General Medicine