First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2

Author:

Jiang Ning-Zu,Bai Ming-Zhen,Huang Chong-Fei,Ma Ze-Long,Zhong Ru-Yang,Fu Wen-Kang,Gao Long,Tian Liang,Mi Ning-Ning,Ma Hai-Dong,Lu Ya-Wen,Zhang Zi-Ang,Zhao Jin-Yu,Yu Hai-Ying,Zhang Bao-Ping,Zhang Xian-Zhuo,Ren Yan-Xian,Zhang Chao,Zhang Yong,Yue Ping,Lin Yan-Yan,Meng Wen-Bo

Abstract

Inflammatory bowel disease (IBD) has as a main characteristic the exacerbation of the immune system against enterocytes, compromising the individual’s intestinal microbiota. This inflammatory cascade causes several nutritional deficiencies, which further compromise immunological functioning and, as a result, worsen the prognosis. This vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition, acting directly on the inflammatory process of IBD through the interaction of food, intestinal microbiota, and epigenome. Specific nutritional intervention for IBD has a crucial role in preventing and managing disease activity. This review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

Publisher

Baishideng Publishing Group Inc.

Subject

Gastroenterology,General Medicine

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