Abstract
Aim: In the present study, zinc oxide nanoparticles (ZnO NPs) were synthesized using Polianthes tuberosa flower concentrate. Antimicrobial and anti-inflammatory efficiency of the green synthesized ZnO NPs were analysed under in vitro conditions. Methodology: Nanoparticles formation was confirmed by UV-visible spectroscopy. Size, shape and morphology of the green synthesized ZnO NPs was determined by SEM coupled with EDAX and AFM. Molecular and elemental compositions of the nanoparticle were determined by XRD and FT-IR analyses. Results: X-ray diffraction analysis depicted the hexagonal wurtzite structure of ZnO NPs with a particle size of 80 nm. The FT-IR analysis illustrated the functional groups responsible for the encapsulation and stabilization of ZnO NPs. At micromolar concentration, ZnO NPs was found to inhibit the growth of selected skin pathogens and suppress biofilm formation in Pseudomonas aeruginosa. Interpretation: P. tuberosa flower concentrate and green synthesized ZnO Nps inhibited the growth of bacterial and fungal pathogen in a dose-dependent manner. Biofilm inhibitory efficiency and anti-inflammatory activity of the zinc oxide nanoparticle illustrated that it can be used for treating skin infections. Key words: Anti-biofilm, Anti-inflammatory, Polianthes tuberosa, Zinc oxide nanoparticles