Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase-Reference-Cited by-同舟云学术

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Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Published:2019-05 Issue:5 Volume:60 Page:953-962
ISSN:0022-2275
Container-title:Journal of Lipid Research
language:en
Short-container-title:Journal of Lipid Research

Author:

Harrison Peter J.,Gable Kenneth,Somashekarappa Niranjanakumari,Kelly Van,Clarke David J.,Naismith James H.,Dunn Teresa M.,Campopiano Dominic J.

Funder

Biotechnology and Biological Sciences Research Council

Uniformed Services University of the Health Sciences

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference52 articles.

1. Sphingolipid biosynthesis in man and microbes;Harrison;Nat. Prod. Rep.,2018

2. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics;Merrill;Chem. Rev.,2011

3. Sphingolipids and their metabolism in physiology and disease;Hannun;Nat. Rev. Mol. Cell Biol.,2018

4. Structural, mechanistic and regulatory studies of serine palmitoyltransferase;Lowther;Biochem. Soc. Trans.,2012

5. The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis;Yard;J. Mol. Biol.,2007

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1. Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition;Microbiology Spectrum;2022-10-26

2. Convergent evolution of bacterial ceramide synthesis;Nature Chemical Biology;2021-12-30

3. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex;Nature Structural & Molecular Biology;2021-02-08

4. Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect;Journal of Enzyme Inhibition and Medicinal Chemistry;2021-01-01

5. Semi-rational approach to expand the Acyl-CoA Chain length tolerance of Sphingomonas paucimobilis serine palmitoyltransferase;Enzyme and Microbial Technology;2020-06

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