Potassium and hypomagnesaemic tetany in calves

Abstract

1. Four groups of four calves were given rations containing adequate and inadequate amounts of magnesium, both with or without an excess of potassium, added as potassium chloride.2. The excess of potassium resulted in the death of three of the eight calves, the clinical signs observed before death being cardiac insufficiency, oedema, severe muscular weakness and muscular atony. The excitability of motor nerves, measured by the method of Kugelberg (1944), was reduced by excess dietary potassium and the serum concentration of potassium was increased. The potassium content of the erythrocytes declined with age, irrespective of dietary treatment.3. Although this evidence of potassium intoxication was obtained, no concomitant abnormalities were induced in magnesium metabolism by the excess of potassium whether or not the calves received rations containing adequate or inadequate amounts of magnesium.4. Excess potassium had no effect on the concentration of potassium or magnesium in the muscle or on the Ca : Mg ratio in bone.5. Magnesium deficiency resulting in tetany was shown to have no statistically significant effect on the intracellular concentration of magnesium i n the muscle. A very small drop in erythrocyte magnesium was noted. No effect on the excitability of motor nerves was observed.6. The results suggest that the effect of excessive manuring of pastures with potassic fertiliser in increasing the incidence of hypomagnesaemic tetany is not due to a direct effect of potassium on the magnesium metabolism of the animal.