The effects of selection for high and low body weight on the proportion and distribution of fat in mice

Abstract

ABSTRACTThe growth of adipose tissue was investigated in lines of mice selected for high and low body weight at 5 and 10 weeks of age, by dissecting and weighing individual fat depots from mice aged 5, 7·5, 10 and 15 weeks. At fixed ages most depots were heavier in the High lines and lighter in the Low lines. Depots grew at different rates and the rate of total fat deposition relative to gain in body weight was greater in High than in Low lines. At about 20g live weight High and Low lines had similar proportions of total fat; at lower weights the High lines were relatively leaner. These correlated effects of selection were more pronounced in the faster growing depots of the kidneys and gonads. In consequence, the High an d Low lines had different fat distributions at fixed ages, at fixed body weights and at fixed weights of fat.