Clear cell carcinoma arising in a pleomorphic adenoma of the submandibular gland

Author:

Cassidy Michael,Connolly Charles E.

Abstract

AbstractClear cell carcinoma of salivary gland is a rare neoplasm. We report a third case of clear cell carcinoma arising in a pleomorphic adenoma and also in an extraparotid location. We document the immunohistochemical profile of the tumour including reactivity with a marker for the c-erbh-2 oncoprotein and suggest a myoepithelial origin for these lesions. The presence of a tetraploid stemline may account for the rapid tumour progression in this case.

Publisher

Cambridge University Press (CUP)

Subject

Otorhinolaryngology,General Medicine

Reference19 articles.

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