Author:
Klossek Jean-Michel,Dubreuil Luc,Richet Hervé,Richet Béatrice,Beutter Patrice
Abstract
AbstractThe aim of this work was to study the bacterial flora of purulent secretions during chronic rhinosinusitis. We studied a total of 533 patients divided into two groups. The control population consisted of 139 adults (> 16 years) of both sexes seen in the community or hospitalized for less than 72 hours for non-rhinological conditions. The rhinosinusitis group consisted of 394 patients referred to the ENT clinic with chronic rhinosinusitis. All the patients with rhinosinusitis had had a post-nasal discharge for at least three months, associated with purulent or mucopurulent secretions originating from the involved sinus cavity. All samples were obtained endonasally under endoscopic guidance from the sinus ostium or from the sinus cavity during surgery. Cultures were positive in 81.3 per cent of the control subjects and 83.1 per cent of the patients with rhinosinusitis.Corynebacteria, coagulase-negative staphylococci, propionibacteria and peptostreptococci were the main commensal organisms, whileHaemophilus influenzae, streptococci,Streptococcus pneumoniae, Prevotellaspp andFusobacteriumspp were probable causative pathogens. Anaerobes were isolated from approximately 25 per cent of the patients in the rhinosinusitis group. Betalactamase producers represented 27.5 per cent ofH. influenzaeand 28 per cent ofPrevotellaspp isolates. Diminished susceptibility to penicillin was found in 13 per cent ofS. pneumoniaeisolates. The amoxycillin-clavulanate combination was the most active oral antibiotic tested against the pathogenic species in vitro.
Publisher
Cambridge University Press (CUP)
Subject
Otorhinolaryngology,General Medicine
Cited by
77 articles.
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