Impact of parental onchocerciasis and intensity of transmission on development and persistence ofOnchocerca volvulusinfection in offspring: an 18 year follow-up study

Abstract

This study analysed the impact and the extent by which parentalOnchocerca volvulusinfection, intensity of transmission ofO. volvulusinfective 3rd-stage larvae (L3) and anthropometric factors may influence the acquisition, development and persistence ofO. volvulusinfection in offspring. A total of 15 290 individuals in 3939 families with 9640 children were surveyed for microfilariae ofO. volvulus, and prevalence and level ofO. volvulusinfection in children aged 0 to 20 years from infected and non-infected parents were followed longitudinally for 18 years. Children fromO. volvulus-infected mothers had not only a substantially higher risk to become infected; they also acquired infection earlier in life and developed higher infection levels. Multiple logistic regression analysis showed that maternalO. volvulusinfection and children's age are the predominant predictors for patentO. volvulusinfection, while the intensity of transmission, measured by the annual transmission potential (ATP) ofO. volvulusL3, was less decisive. Longitudinal follow up of children showed that during vector control activities by the Onchocerciasis Control Programme (OCP) and in low-level transmission areas, infection persisted at higher levels in children fromO. volvulus-positive mothers. In summary, the dominant risk factor for children to become infected is maternal onchocerciasis, and also age-associated factors will strongly impact on the development of patentO. volvulusinfection in offspring.