Author:
WINTER M. D.,WRIGHT C.,LEE D. L.
Abstract
Helminthologically naive 8-week-old lambs were administered
50000 infective-stage larvae of the trichostrongyle nematode
Nematodirus battus. Initial mean adult worm burdens were significantly
reduced (P < 0·01) at day 21 post-infection
(p.i.). Peripheral blood eosinophil counts showed a significant increase
(P < 0·001) by day 25 p.i. when compared with
uninfected control animals. Sections of small intestine taken at
post-mortem from the area of adult worm establishment
over the course of infection showed a significant increase in mucosal
eosinophil and mast cell numbers during the period
of adult worm rejection, when compared with uninfected control animals.
These results show that young lambs develop
significant increases in the numbers of cells associated with an
inflammatory reaction in the intestine during the
development of a partially protective immune response to this parasitic
nematode.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献