Author:
GANAPAMO F.,RUTTI B.,BROSSARD M.
Abstract
BALB/c mice infested with larvae or nymphs of Ixodes
ricinus develop in their lymph nodes a T cell-specific immune
response triggered by salivary gland soluble antigens (SGA). SGA are
apparently conserved in the 3 biological stages of
I. ricinus ticks and are species specific. SGA derived from
partially fed females I. ricinus stimulate lymph node T cells from
mice infested with I. ricinus larvae or nymphs. In contrast,
lymph node cells from mice infested with Amblyomma hebraeum
nymphs do not respond. A chromatographic fraction enriched with a
65 kDa protein (IrSG65) isolated from salivary
glands of I. ricinus partially fed females induces in vitro
a specific T cell proliferation of lymph node cells from mice
infested with I. ricinus nymphs. The depletion of CD4+ T
cells drastically reduces the ability of lymphocytes from infested
mice to proliferate after IrSG65 stimulation.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
10 articles.
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