Abstract
AbstractHuman infections withTrichinella spiralisand respiratory syncytial virus (RSV) are common, asT. spiralisinfections are re-emerging in various parts of the world and RSV infections remain a threat for infants. Yet, studies investigating the relationship pertaining to the two are severely lacking. In particular, immune response inductionviaRSV andT. spiralisremain largely elusive. Here, we investigated the resistance againstT. spiralisinfection induced upon primary infection with RSV. RSV, notorious for causing severe inflammatory reaction in the lungs, were intranasally infected, followed with aT. spiralisinfection in mice. Our results revealed that primary RSV infection in mice significantly raisedT. spiralis-specific and total IgE, IgG and its subclass antibody responses uponT. spiralischallenge infection (RSV-Ts). Blood eosinophil levels were decreased in RSV-Ts, accompanied with significant increase in both Th1 and Th2 cytokines. Antibodies generated against RSV in RSV-infected mice were found to react withT. spiralisexcretory/secretory antigen, showing several bands determined through immunoblotting. RSV-Ts also had a marked reduction ofT. spiralisworm burden in diaphragm. These results indicate that immune responses induced by RSV infection contribute to resistance against subsequentT. spiralisinfection.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
11 articles.
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