Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice-Reference-Cited by-同舟云学术

Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Published:1993-11 Issue:4 Volume:107 Page:411-417
ISSN:0031-1820
Container-title:Parasitology
language:en
Short-container-title:Parasitology

Author:

Müller N.,Imboden M.,Detmer E.,Mansfield J. M.,Seebeck T.

Abstract

SUMMARYSerum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Animal Science and Zoology,Parasitology

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