Mechanism of skin penetration byAncylostoma tubaeformelarvae

Abstract

Skin penetration by infectiveAncylostoma tubaeformelarvae has been investigated cinematographically and usingin vitrotechniques. The dermal tissue appears to cause little hindrance to larval migration but complete penetration through the skin from the dermal direction did not occur, although total penetration from the epidermal surface was frequently accomplished. No evidence could be found for enzymic secretions emanating from the worms under conditions that gave positive results fromNecator americanusandStrongyloides fülleborniinfective larvae. The results indicated thatA. tubaeformewas able to penetrate without the use of enzymic secretions and an alternative, mechanical mechanism for penetration is advanced.