A basis to extend the proof of migration routes of immature parasites inside hosts: estimated time of arrival of Nippostrongylus brasiliensis and Strongyloides ratti in the gut of the rat

Abstract

SUMMARYThe time taken for larvae of Nippostrongylus brasiliensis and a homogonic strain of Strongyloides ratti to complete their migration from the skin surface to the small intestine of the rat was estimated by a new method in which a mirror image of arrival times was created by counting mature parasites at day 8 (N. brasiliensis) or day 5 (S. ratti) in the intestines of rats that had received a single pulse of morantel tartrate by stomach tube at different times starting 10 h after skin application of exact doses of infective larvae. It was confirmed that the effect of the drug was confined to parasites in the gut, so that the kinetics of migration were unperturbed.