Author:
Bishop Ann,McConnachie Elspeth W.
Abstract
1. A four- to eight-fold increase in resistance to pamaquin has been developed in a strain of Plasmodium gallinaceum in chicks.2. Pamaquin resistance conferred no resistance to proguanil, sulphadiazine, mepacrine, chloroquine or sontochin, but it conferred some resistance to pentaquine and to quinine.3. An appreciable loss in resistance to pamaquin was observed in the pamaquin-resistant strain after it had been maintained in the absence of the drug, in a patent state of infection, for a period of 6 months.4. No synergism was observed between pamaquin and quinine when these drugs were tested, in combined doses, upon active infections of P. gallinaceum.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Reference36 articles.
1. STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VIII. THE PHYSIOLOGICAL DISPOSITION OF PAMAQUINE 123
2. On the Ability of Plasmodium Lophurae to Acquire Resistance to Chlorguanide, Camoquin and Chloroquine
3. Studies in malaria, with special reference to treatment. IX. Plasmoquine in the treatment of malaria;Sinton;Indian J. Med. Res.,1928
4. Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi;Schmidt;J. Pharmacol.,1949
5. Acquired Paludrine-Resistance inPlasmodium Gallinaceum
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