Comparison of single and split-dose flubendazole treatment for the nematode parasiteTrichostrongylus tenuisin experimentally infected grey partridgesPerdix perdix

Abstract

SUMMARYDifferent therapeutic regimes using flubendazole for the treatment ofTrichostrongylus tenuisinfection in experimentally infected grey partridgesPerdix perdixwere examined. Flubendazole dosages of 4, 8 and 20 mg/kg were administered orally as a single dose or split into 3 or 9 parts given over 9 days. The efficacy against adult worms in the caeca improved with dose rate. Split doses were at least as effective as single doses, which removed up to 83% of adultT. tenuis. A dose of 20 mg/kg administered on a daily basis over 3 or 9 days gave the best clearance ofT. tenuis, resulting in a reduction of at least 95% in worm burden.