Author:
HOSEIN SHAZIA,BLAKE DAMER P.,SOLANO-GALLEGO LAIA
Abstract
SUMMARYCanine leishmaniosis (CanL) is caused by the parasiteLeishmania infantumand is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated withLeishmaniaspecies makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated withL. infantuminfection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
76 articles.
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