Strain variation in Entamoeba histolytica I. Correlation of invasiveness in rats with the clinical history and treatment of the experimental infections

Author:

Neal R. A.,Vincent Patricia

Abstract

1. Eleven strains of Entamoeba histolytica were isolated from contact carriers and all proved non-invasive to rats.2. Three strains from cases showing symptoms proved invasive to rats.3. The treatment of murine infection with non-invasive strains with emetine hydrochloride shows that most of them were successfully cured with six daily oral doses of 2 mg./kg., though one was not susceptible to this dose. Another proved refractory to 4 mg./kg.4. The results of previous work with kittens are discussed in the light of the present observations.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Animal Science and Zoology,Parasitology

Reference33 articles.

1. Étude sommaire de l'Entamoeba dispar n.sp. Amibe àkystes quadrinueléés, parasite de l'homme;Brumpt;Bull. Acad. Méd. Paris,1925

2. Observations on Natural Infections of Endamoeba Histolytica in Ateles and Rhesus Monkeys 1

3. Researches on the Intestinal Protozoa of Monkeys and Man. IV. An experimental study of the Histolytica-like species of Entamoeba living naturally in Macaques

4. Studies of Endamoeba histolytica and other intestinal protozoa in Tennessee. V. A comparison of five strains of E. histolytica with reference to their pathogenicity for kittens;Meleney;Amer. J. Hyg.,1933

5. Experiments on the therapeutics of amoebic dysentery;Dale;J. Pharmacol.,1917

Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Amebiasis;Clinical Microbiology Reviews;1992-10

2. A mouse model for Entamoeba histolytica infection;Laboratory Animals;1985-10-01

3. Entamoeba Histolytica: Electrophoretic Isoenzyme Patterns of Strains and their Virulence in the Cecum of Gerbils (Meriones Unguiculatus);The American Journal of Tropical Medicine and Hygiene;1985-09-01

4. Virulence of Entamoeba histolytica in rat and its comparison with the serological responses of the amoebic patients;Transactions of the Royal Society of Tropical Medicine and Hygiene;1981-01

5. Some observations on the pathogenicity of strains of Entamoeba histolytica;Transactions of the Royal Society of Tropical Medicine and Hygiene;1971-01

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