The relationship between IgA activity against 4th-stage larvae and density-dependent effects on the number of 4th-stage larvae ofTeladorsagia circumcinctain naturally infected sheep

Abstract

The number ofTeladorsagia circumcincta4th-stage larvae in naturally infected lambs from a single farm varied among lambs and among different years. Within each year the distribution of 4th-stage larvae among lambs was similar to that expected from a negative binomial distribution. The ratio of 4th-stage larvae to adultT. circumcinctawas low in two years with a low mean intensity of infection but high in two years with a higher mean intensity of infection. The negative binomial distribution is defined by the mean and byk, a parameter that measures dispersion;kwas low when mean infection intensity was low but higher when mean infection intensity was high. Askis an inverse index of overdispersion this indicated that the distribution of 4th-stage larvae was more overdispersed at low levels of infection. In a combined analysis, the number of adultT. circumcinctaand the plasma IgA activity against 4th-stage larvae were both associated with increased numbers of 4th-stage larvae. There was a statistical interaction between the number of adults and IgA activity that moderated their combined effect.