The Role of 5-HT1B/1D Receptors in the Treatment of Migraine-Reference-Cited by-同舟云学术

The Role of 5-HT1B/1D Receptors in the Treatment of Migraine

Published:1998-09 Issue:8 Volume:3 Page:30-39
ISSN:1092-8529
Container-title:CNS Spectrums
language:en
Short-container-title:CNS spectr.

Author:

Waeber Christian

Abstract

AbstractOf all known neurotransmitters, 5-HT is the one most frequently mentioned in the pathophysiology of migraine. This review focuses on the relationship between the efficacy of sumatriptan and other migraine agents and their effects on specific 5-HT receptors in rodent models. These agents are seen to have effects on vascular constriction and the release of vasoactive and inflammatory peptides from trigeminovascular sensory neurons. Specific subtypes of the 5-HT1 receptors appear to mediate these effects.

Publisher

Cambridge University Press (CUP)

Subject

Psychiatry and Mental health,Clinical Neurology

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