Author:
Biederman Joseph,McDonnell Mary Ann,Wozniak Janet,Spencer Thomas,Aleardi Megan,Falzone Richard,Mick Eric
Abstract
ABSTRACTBackgroundPediatric bipolar diorder is a serious neuropsychiatric disorder asociated with high levels of morbidity and disabilty.ObjectiveThis is a systematic chart review of all outpatient youth with the diagnosis of bipolar disorder and bipolar spectrum disorder treated with aripiprazole either alone or as add-on to ongoing treatments.MethodMedical records were reviewed to identify all subjects with bipolar and bipolar spectrum disorder prescribed aripiprazole in our clinic. During the chart review, the Clinical Global Impression scale was completed by the treating clinicians to determine usefullness.ResultsForty-one youths (mean age±SD: 11.4±3.5 years) with bipolar spectrum disorder who had been treated with aripiprazole were identified. These children received a mean daily dose of aripiprazole 16.0±7.9 mg over an average of 4.6 months. Using a Clinical Global Impression-Improvement scale score of <2 (very much/much improved) to define robust improvement, 71% showed improvement in manic symptoms. Treatment with aripiprazole was well tolerated.ConclusionThis study suggests that aripiprazole may be a useful and well-tolerated treatment for youth with bipolar disorder and it supports the need for controlled clinical trials of this compound in juvenile mania.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical)
Cited by
72 articles.
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