Molecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC)

Author:

Pollard Courtney,Smith Steven C.,Theodorescu Dan

Abstract

Urothelial carcinoma (UC) is the most common type of bladder cancer in Western nations. Most patients present with the non-muscle-invasive (NMIUC) form of the disease, while up to a third harbour the invasive form (MIUC). Specifically, the aetiology of NMIUC appears to be multifactorial and very different from that of MIUC. Loss of specific tumour suppressor genes as well as gain-of-function mutations in proteins within defined cellular signalling pathways have been implicated in NMIUC aetiology. The regions of chromosome 9 that harbourCDKN2A,CDKN2B,TSC1,PTCH1andDBC1are frequently mutated in NMIUC, resulting in functional loss; in addition,HRASandFGFR3, which are both proto-oncogenes encoding components of the Ras–MAPK signalling pathway, have been found to harbour activating mutations in a large number of NMIUCs. Interestingly, some of these molecular events are mutually exclusive, suggesting functional equivalence. Since several of these driving changes are amenable to therapeutic targeting, understanding the signalling events in NMIUC may offer novel approaches to manage the recurrence and progression of this disease.

Publisher

Cambridge University Press (CUP)

Subject

Molecular Biology,Molecular Medicine

Reference154 articles.

1. FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder;Bakkar;Cancer Research,2003

2. Mutation of H-ras Is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing;Knowles;Cancer Research,1993

3. Deletion of the p16 and p15 Genes in Human Bladder Tumors

4. Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation

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