Interference ofPseudomonas aeruginosasignalling and biofilm formation for infection control

Abstract

Pseudomonas aeruginosais the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed ofP. aeruginosaare thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour ofP. aeruginosain vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour ofP. aeruginosa, and how to treat chronic infections of this bacterium in patients.