Author:
Macedo Andréa M.,Oliveira Riva P.,Pena Sérgio D.J.
Abstract
Chagas disease, caused by the parasite protozoan Trypanosoma cruzi, is characterised by a variable clinical course, from symptomless cases to severe chronic disease with cardiac and/or gastrointestinal involvement. This variability has been attributed both to differences in the host response and to genomic heterogeneity of the parasite. This article reviews the evidence in favour of an important role of the genetic constitution of T. cruzi in determining the clinical characteristics of Chagas disease and discusses the basis of the ‘Clonal-Histotropic Model’ for the pathogenesis of this disease.
Publisher
Cambridge University Press (CUP)
Subject
Molecular Biology,Molecular Medicine
Cited by
43 articles.
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