Histochemical localization and possible antibacterial role of xanthine oxidase in the bovine mammary gland

Author:

Collins Robert A.,Parsons Keith R.,Field Terry R.,Bramley A. John

Abstract

SummaryXanthine oxidase (XO) was demonstrated to be present in the teat canal and secretory tissue of the bovine mammary gland by histochemical techniques. Homogenates of these tissues were able to replace XO in an antibacterial assay with Streptococcus uberis. The action of XO on its substrate hypoxanthine was shown to provide an essential component for anti-streptococcal activity mediated by lactoperoxidase. A mechanism is proposed whereby the interaction of XO, lactoperoxidase and thiocyanate may provide antibacterial activity in the teat canal.

Publisher

Cambridge University Press (CUP)

Subject

Animal Science and Zoology,General Medicine,Food Science

Reference22 articles.

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3. Reiter B. & Bramley A. J. 1975 Defence mechanisms of the udder and their relevance to mastitis control. International Dairy Federation Bulletin Document no. 85 210–222

4. The inhibition of streptococci by lactoperoxidase, thiocyanate and hydrogen peroxide. The effect of the inhibitory system on susceptible and resistant strains of group N streptococci

5. Comparison of the antibacterial activity of the hypothiocyanite anion towards Streptococcus lactis and Escherichia coli;Marshall;Journal of General Microbiology,1980

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