Possible antidepressant/mania-inducing effects of methionine: a reappraisal of the effects of methionine in chronic psychosis using modern diagnostic criteria
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Published:1989
Issue:3
Volume:4
Page:175-181
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ISSN:0767-399X
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Container-title:Psychiatry and Psychobiology
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language:en
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Short-container-title:Psychiatr. psychobiol.
Author:
Lipinski J.F.,Alexander R.C.
Abstract
SummaryThe authors have reviewed 13 published studies on methionine administration, usually in combination with a monoamine oxidase inhibitor (MAOI), to chronically psychotic patients, using modern (DSM-III) diagnostic criteria. Four of these studies contained sufficient descriptive data to allow reappraisal of the effects. The results of the review suggest that a proportion of the patients experienced the induction of a manic episode/antidepressant effects rather than the reported worsening of schizophrenia while treated with a methionine-MAOI combination. It is suggested that these observations are consistent with recent findings that S-adenosyl-L-methionine (SAMe) has antidepressant and mania-inducing effects.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health
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