Studies on the Liver, Lung, Brain and Blood of Experimental Animals Infected withToxocara canis

Abstract

Studies were carried out in mice and a monkey (paratenic hosts) and pathological lesions in mice have been described in liver, lung and brain withToxocaralarvae moving actively in the tissues causing damage (haemorrhages and necrosis) with encystment. In both mice and monkey there is essentially an eosinophilic response with lymphocytes and neutrophils also showing rise in the peripheral blood a few days after infection. In mice lymphocytes are the predominant tissue inflammatory cell.