Author:
Bylund G.,Bång B.,Wikgren K.
Abstract
ABSTRACTPraziquantel (Droncit) is a new anthelminthic agent with a strikingly wide therapeutic index. The efficiency of the drug against Diphyllobothrium latum was tested in vivo and in vitro. With a drug dose of 50 mg/kg, artificially infected hamsters were completely cured. The threshold value of the active dose was between 2·5 and 10·0 mg/kg. Clinical trials with Praziquantel against human diphyllobothriasis show great promise, all of ten patients treated with 25·0 mg/kg of the drug being cured. Praziquantel had little effect on larval or adult diphyllobothriids in vitro.
Publisher
Cambridge University Press (CUP)
Subject
Animal Science and Zoology,General Medicine,Parasitology
Reference3 articles.
1. Zur Wirksamkeit von Praziquantel gegen Bandwürmer in experimentell infizierten Hunden und Katzen;Rommel;Berliner und Münchener Tierärztliche Wochenschrift,1976
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