Experimental infection of Ancylostoma caninum in mice. II. Migration and distribution of larvae in tissues after oral infection

Abstract

AbstractMigration and distribution of Ancylostoma caninum larvae in the tissues of Swiss albino mice infected with 500,1000, 2000 and 4000 larvae was studied. Larval migration and distribution in the different tissues was earlier in mice infected with a dose of 4000 larvae and more larvae were expelled from the gastrointestinal tract of heavily infected (2000 dose) mice. With an infective dose of 1000 larvae, the percent larval yield was higher than in other two groups (500 dose and 2000 dose) showing poor expulsion. Larval migration in the lungs was high even on the 1st day in heavily infected groups. Migration of larvae into the muscles, particularly of the head, neck and thorax took place on the very first day and was proportional to dose level. Larval count was higher in the muscles of the head and neck until the 9th day, after which it was high in the thoracic and other regions.