Author:
Zepeda N.,Tirado R.,Copitin N.,Solano S.,Fernández A.M.,Tato P.,Molinari J.L.
Abstract
AbstractThis study was undertaken to determine whether a parasite substance produces structural pathology in the mouse spleen. A low-molecular-weightTaenia crassicepsmetacestode factor (MF) isolated from the peritoneal fluid of female mice infected withT. crassicepsmetacestodes induced pathological and immunological changes in mouse spleen cellsin vivo.Electron microscopy and confocal microscopy revealed severe changes in the spleen histoarchitecture ofT. crassiceps-infected and MF-treated mice. Apoptotic degenerated spleen cells were observed in the white and red pulps and were more conspicuous in the white pulp of the spleen from theT. crassiceps-infected mice than in that of the MF-treated mice. Flow cytometry analysis revealed that the numbers of spleen CD4+T cells were significantly lower in both experimental groups than in control mice. Theex vivoexpression of transforming growth factor (TGF)-β and factor Foxp3 were significantly higher in splenocytes of the experimental mice than the basal expression observed in the control cells. These findings may have potential applications for a better understanding of the host–parasite relationship in human neurocysticercosis.
Publisher
Cambridge University Press (CUP)
Subject
Animal Science and Zoology,General Medicine,Parasitology
Cited by
6 articles.
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