Abstract
AbstractObjective:Previous studies evaluating the associations of circulating Zn and Se levels with asthma have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize and quantitatively synthesize the evidence from observational research.Design:Meta-analysis.Setting:We searched PubMed, Web of Science and Scopus databases up to May 2019 for relevant available articles. Random-effects model was adopted to estimate the pooled standardized mean difference (SMD) with 95 % CI. Meta-regression analysis and ‘leave-one-out’ sensitivity analysis were used to assess heterogeneity.Participants:The meta-analysis focused on general populations.Results:A total of twenty-six studies for Zn and forty studies for Se were included in the meta-analysis. The overall analyses identified that asthma patients had lower Zn (SMD = −0·40; 95 % CI −0·77, −0·03; I2 = 94·1 %) and Se (SMD = −0·32; 95 % CI −0·48, −0·17; I2 = 90·9 %) levels in serum or plasma compared with healthy controls. After removing the studies that contributed to the heterogeneity, the pooled SMD were −0·26 (95 % CI −0·40, −0·13; I2 = 37·42 %) for Zn and −0·06 (95 % CI −0·13, 0·02; I2 = 43·54 %) for Se.Conclusions:Lower circulating Zn and Se levels might be associated with an increased risk of asthma.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
13 articles.
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