Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a controlled clinical trial

Abstract

SynopsisAn account is given of a multi-centre, controlled clinical trial of the comparative efficacy of lithium, amitriptyline and placebo in terms of the comparative relapse-rates over a three-year period among patients who had recovered from a depressive illness. The results indicate that while both the pharmacodynamically active drugs are more effective than placebo the differences between them are minimal.