Thyrotropin releasing hormone (TRH) as a possible quick-acting but short-lasting antidepressant

Author:

Van Den Burg W.,Van Praag H. M.,Bos E. R. H.,Piers D. A.,Van Zanten A. K.,Doorenbos H.

Abstract

SynopsisIn a double reversal design the potency of thyrotropin releasing hormone (TRH) (500 μgintravenously) as a quick-acting antidepressive agent was evaluated. A first injection did seem to give rise to a very slight short-lasting effect, though this could not be ascertained clearly. There were no visible effects after a second injection. The thyroid stimulating hormone (TSH) response curve after TRH administration in the depressive patients group was blunted in comparison with that in a matched control group of normals.

Publisher

Cambridge University Press (CUP)

Subject

Psychiatry and Mental health,Applied Psychology

Reference28 articles.

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