Author:
KENDLER KENNETH S.,GARDNER CHARLES O.
Abstract
Background. Although replication is the heart of
science, psychiatric geneticists rarely have the opportunity to
replicate findings, especially more than once.Methods. This article reviews results from three
independent family studies of schizophrenia on which one of us
conducted diagnostic reviews: the Danish Adoption Study (DAS), the
Iowa 500 non-500 family study (IFS), and the Roscommon Family Study
(RFS). We utilized DSM-III or DSM-III-R criteria and meta-analysis
techniques.Results. The odds ratios (OR) in personally interviewed,
first degree biological relatives of schizophrenic and matched control
probands for schizophrenia, other non-affective psychoses (ONAP),
schizotypal personality disorder (SPD), unipolar affective illness
(UPAI), bipolar affective illness (BPAI), and anxiety disorders were
homogeneous across studies. For alcoholism, ORs were significantly
heterogeneous. Schizophrenia, SPD and ONAP strongly aggregated in
relatives of schizophrenic probands with decreasing common OR
estimates of 16·2, 5·0 and 4·0, respectively. The
common OR for anxiety disorders was 1·1, indicating no familial
co-aggregation. For UPAI and BPAI, the common ORs exceeded unity
(1·3 and 1·9, respectively), although only the former
was statistically significant.Conclusions. Schizophrenia strongly aggregates in families
and shares familial factors with SPD and ONAP but not anxiety
disorders. The familial factors of aetiological importance for
schizophrenia and affective illness may be weakly related. With the
exception of alcoholism, the patterns of psychiatric disorders in
relatives of schizophrenic and control probands in these three studies
were sufficiently similar that, despite their methodological
differences, they can probably be viewed as replications of one
another.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Applied Psychology
Cited by
116 articles.
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