Author:
STUVE T. A.,FRIEDMAN L.,JESBERGER J. A.,GILMORE G. C.,STRAUSS M. E.,MELTZER H. Y.
Abstract
Background. In this study, we tested the hypothesis that low smooth pursuit gain in
schizophrenia is related to an abnormality in motion perception.Methods. The subjects were 19 schizophrenics treated with clozapine and 19 controls. In addition
to smooth pursuit and motion perception paradigms, sustained attention was also assessed
using a continuous performance task (CPT).Results. In the patient group, there was a statistically significant negative correlation between
smooth pursuit gain and motion perception threshold (r =−0·60, P<0·01). This relationship
was not secondary to attention deficits as assessed by the CPT.Conclusions. Our results are consistent with the notion that the smooth pursuit gain deficit is
related to a deficit in motion perception rather than in attention. Brain area V5 (also referred to
as ‘MT’ in macaque), located in the parieto-occipital region, is known to be critically important
both for motion perception and gain. Thus, our results point to an abnormality in this area in
schizophrenia.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Applied Psychology
Cited by
109 articles.
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