Author:
Germinario Ralph J.,Oliveira Maureen,Manuel Susannia
Abstract
ABSTRACTInsulin (0.67 μM) and serum (10% v/v) stimulated hexose transport did not change within vitroageing of cultured human skin fibroblasts. Additionally, dexamethasone amplification of the insulin-stimulated response which yielded responses to near physiological concentrations of insulin (i.e. 6.7 nM), showed no changes within vitroageing. Basal (i.e. nonstimulated) hexose transport, either in the presence or absence of dexamethasone, did not change within vitroageing. Thein vitroloss of proliferative potential duringin vitroageing of cultured human fibroblasts probably does not involve changes in short term insulin responses (e.g. stimulation of hexose transport).
Publisher
Cambridge University Press (CUP)
Subject
Geriatrics and Gerontology,Community and Home Care,Gerontology,Health(social science)
Cited by
1 articles.
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