Author:
Surakka Ida,Whitfield John B.,Perola Markus,Visscher Peter M.,Montgomery Grant W.,Falchi Mario,Willemsen Gonneke,de Geus Eco J. C.,Magnusson Patrik K. E.,Christensen Kaare,Sørensen Thorkild I. A.,Pietiläinen Kirsi H.,Rantanen Taina,Silander Kaisa,Widén Elisabeth,Muilu Juha,Rahman Iffat,Liljedahl Ulrika,Syvänen Ann-Christine,Palotie Aarno,Kaprio Jaakko,Kyvik Kirsten O.,Pedersen Nancy L.,Boomsma Dorret I.,Spector Tim,Martin Nicholas G.,Ripatti Samuli,Peltonen Leena
Abstract
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene–environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol,rs2483058in an intron ofSRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P= 3.98 × 10−8). We followed up the association in further genotyped monozygotic twins (N= 1,261), which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P= 4.03 × 10−8).
Publisher
Cambridge University Press (CUP)
Subject
Genetics (clinical),Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献