Psychiatric shades of grey: mirtazapine-induced hair discoloration and hair loss

Author:

Osman M.,McCauley M. D.

Abstract

IntroductionMirtazapine is indicated in the treatment of major depressive disorder particularly in selective serotonin re-uptake inhibitors resistance. Its effect on hair loss is rare with no previous documented effect on hair colour.MethodReview of relevant literature and description of a case report of a 54-year-old male patient who developed alopecia and hair discoloration after initiation of mirtazapine treatment.ResultsUpon cessation of mirtazapine treatment full restoration of hair colour and regrowth of hair was attained within 10 weeks.DiscussionThere was clear temporal relationship between experiencing hair loss and commencing mirtazapine treatment. No other more likely medical reason to explain such experience was established. A noticeable restoration of the hair colour occurred following mirtazapine cessation.ConclusionMirtazapine is associated with hair discoloration and hair loss. The possibility of such distressing adverse effects needs to be conveyed to patients by clinicians and to be further explored by researchers.

Publisher

Cambridge University Press (CUP)

Subject

History and Philosophy of Science,Psychiatry and Mental health,Applied Psychology

Reference16 articles.

1. Hair Loss in Psychopharmacology

2. The Hair Follicle as a Dynamic Miniorgan

3. Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging

4. Ziekenhuisapotheek Medisch Centrum Leeuwarden/Apotheek Ziekenhuis De Tjongerschans Heerenveen [Drug induced alopecia];van den Bemt;Nederlands Tijdschrift Voor Geneeskunde,1999

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