Nucleotide sequence analysis of class II genes borne by mousetchromosomes

Abstract

SummaryFive class IIH-2genes borne bytchromosomes were partially sequenced:borne by thetTuw10chromosome of EDY589 (H-2w2);andborne by thetTuw8chromosome of CR0437 (H-2w57), as well asandborne by thetTuw7chromosome of CR0435 (H-2w37). These genes are representatives of the three major groups of alleles found associated withtchromosomes. The sequenced part consisted of almost the entire exon 2 and the entire exon 3 coding for the first and the second domain of the β polypeptide chains, respectively. The sequence was compared with the published sequences ofAβandEβalleles borne, by non-tchromosomes. The comparison revealed that thet-associated alleles are no more similar to one another than they are to the corresponding genes present on non-tchromosomes in laboratory mice. This divergence in the nucleotide sequence among the class II genes is interpreted as evidence that thetcomplex is very old.