Tipsy, a new mutant in linkage group VII of the mouse

Abstract

Tipsy (symbol ti) is a fully penetrant recessive mutant in linkage group VII of the mouse. Homozygotes have a peculiar rabbit-like gait from the age of a week, followed soon after by a tendency for the fore-part of the body to sway from side to side, leading to a reeling locomotion with falling over in severely affected mice. There is marked variation in manifestation and some amelioration in older animals; both sexes are fertile.Linkage relationships in group VII are discussed and tipsy is compared with other mutants showing locomotor instability.